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Prof McGowan says that drugs like semaglutide can cause "significant side effects", such as nausea, for some patients, which is why proper medical support is needed

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In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103