semaglutide 1.34 Ozempic 2 mg/1.5 mL (1.34 mg/mL) prefilled pen that delivers 0.25 mg or 0.5 mg per injection Images Weight-Loss Drugs Like GLP-1s Linked

The absolute weight loss associated with semaglutide use is up to 4.6 kg and 6.5 kg at doses of 0.5 mg and 1.0 mg respectively over 40 weeks

However, subsequent research revealed that HGF and its receptor c-Met are widely expressed in the brain, particularly in the hippocampus, cortex, and cerebellum

Clinical trials have demonstrated that Wegovy, when used alongside lifestyle modifications, can result in an average weight loss of approximately 15% of initial body weight over 68 weeks, as reported in the STEP 1 trial and referenced in NICE technology appraisal guidance (TA875)

Key Insight: The contribution to total spend on GLP-1s for members with obesity without a diabetes diagnosis has grown significantly, now constituting almost 16.5% of spend on these drugs compared to 11% in 2022 and just 4% in 2020