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At 12mg weekly, the maximum studied dose, mean weight reduction hit 24.2% in Phase 2 and 28.7% in Phase 3 (TRIUMPH-4)

For each phenotype, we divided the significantly associated proteins into those that were upregulated and those that were downregulated

Key Takeaways In a 2025 study, roughly 10% weight loss on a GLP-1 drug raised the share of men with normal total and free testosterone from 53% to 77% with no hormone therapy given

Pharmacy Guild president Trent Twomey said while there was "zero evidence to prove there is a safety concern" over compounded weight loss drugs, there was also "zero evidence to say that it is safe"