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A 2020 systematic review in the Journal of the American Academy of Dermatology (N=634 across 8 studies) found that oral minoxidil at doses ranging from 0.25 mg to 5 mg daily produced clinically meaningful hair density improvements in 60% to 82% of patients over 6 to 12 months [3]

Specifically, the MTHFR gene codes for an enzyme called methylenetetrahydrofolate reductase that turns folate into the active form, 5-methyltetrahydrofolate

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Oyama Y, Tomiyoshi F, Ueno S, Furukawa K, Chikahisa L (1994) Methylmercury-induced augmentation of oxidative metabolism in cerebellar neurons dissociated from the rats: its dependence on intracellular Ca2+