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While this partial reduction in cholesterol levels appears beneficial for beta cell GLP-1R function, we previously observed that a much more drastic cholesterol extraction using MCD leads to the opposite effect, inhibiting agonist-induced GLP-1R cAMP responses (25), a result that we hypothesise is linked to the profound disruption of plasma membrane architecture caused by MCD (47)

Diabetes (2011) 60(12):31039.10.2337/db11-0979 97 ChristensenMCalannaSSparre-UlrichAHKristensenPLRosenkildeMMFaberJet alGlucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes

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