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During the sleep cycle, the brain efficiently eliminates metabolic waste and neurotransmitters, aiding in the restoration of normal functionality in neurons and brain circuits (Krueger and Obal, 2003)

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Mechanisms linking environmental agents to the development of Autoimmune Diseases Oxidative stress-mediated disturbance of Nrf2, induction of NF-kB, PARP1, and NLRP3 can cause activation of both innate and adaptive immune systems, resulting in pro-inflammatory cytokines and production of autoantibodies, leading to tissue damage in Autoimmune disease