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TCDD targeted the aryl hydrocarbon receptor in the intermembrane space of organelles in mitochondria (miAhR), leading to degradation of miAhR and dysfunction of mitochondria, which clinically manifested as metabolic dysfunction, e.g

The crude material was purified by automated flash column chromatography on silica via gradient elution, from 100% dichloromethane to 1% methanol in dichloromethane to produce SS(NHS-CM) 2 (979 mg, 79%) as an off-white foamy solid

When you do anything to your body, if you do it just once, the likelihood that that's going to work long term is pretty slim

Finan B, Mller TD, Clemmensen C, Perez-Tilve D, DiMarchi RD, Tschp MH