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The trial included nearly 600 adults split into two groups: people with Type 2 diabetes and obesity, and people with obesity alone

[1] [2] Hashimoto's thyroiditis is an autoimmune condition in which the immune system attacks the thyroid gland, leading to chronic inflammation and often resulting in hypothyroidism (underactive thyroid)

The medication's effects on weight, glucose metabolism, and lipids may collectively contribute to reducing cardiovascular risk in this population, though dedicated treatments for each component of metabolic syndrome remain important

In real-world data, the average 3-month weight loss was 5.9% for tirzepatide versus 3.6% for semaglutide