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The compound was designed to provide both high IRAP inhibitory capacity and an improved metabolic stability attributed to the introduction of an -amino acid residue adjacent to the predicted scissile peptide bond

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Prevent metabolic adaptation , allowing for continued weight loss

This type of study is important for several reasons: it tells us how long the peptide remains active in the body, what breakdown products are formed (which could themselves have biological activity or be used as markers in drug testing), and helps explain why AOD9604 needs to be administered in certain ways to remain effective