metformin and semaglutide oral vs Efficacy safety of once-weekly versus daily canagliflozin as add-on to in patients with type 2 diabetes (SUSTAIN 8): Metformin and Ozempic Together: Safety

Those with genetic variations suggesting higher regain risk after discontinuation may benefit from earlier discussion about long-term planning

WeiserMJMuchaBDenheyerHAtkinsonDSchanzNVassiliouEet al

Related Stories Off-label ketamine use for chronic pain lacks scientific basis First new fibromyalgia drug in 15 years, Tonmya (cyclobenzaprine HCl) gains FDA approval and hits pharmacy shelves Study links neuroimmune dysregulation to complex fibromyalgia symptoms Physical therapy is the most effective treatment for fibromyalgia

11 This illustrates that regardless of the drivers of obesity, PwO are in an established state of pathological energy homeostasis that requires intensification of treatment beyond foundational lifestyle changes, and which often requires the use of anti-obesity medications (AOMs)