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Collagen, the most abundant protein in the skin, helps maintain structural integrity, elasticity, and hydration

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Another excitatory G -subunit (G s ) activates the membrane-associated adenylyl cyclase, which catalyzes the conversion of ATP to cAMP, leading to activation of protein kinase A (PKA)

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Additionally, microbial metabolites such as short-chain fatty acids and bile acids are increasingly recognized as modulators of thyroid hormone metabolism, tissue sensitivity, and enterohepatic circulation

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