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Figure 1 Figure 2 The discovery of the second incretin, GLP-1, originated from observations in 1982 that anglerfish proglucagon mRNA contained coding sequences of glucagon-related peptide, flanked by pairs of basic amino acids characteristic of the sites cleaved during post-translational processing of prohormones ( Figure 1 Section A]

The impact of GLP-1 RAs on mortality, MACEs, and MAKEs The crude incidence of mortality rate was 22.91 per 1000 person-years, which was significantly lower in the GLP-1 RAs users group than in the non-users group (6.8% vs

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Some patients have reported severe abdominal pain, hospitalization for acute pancreatitis, and permanent gastrointestinal dysfunction following excessive dosing or rapid escalation