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However, Mendelian randomization studies gave inconsistent results whereas intervention-studies with UA-lowering therapies, particularly with XOR inhibitors, were disappointing in terms of reduction of incident CVD or CVD-related outcomes even though these therapies consistently reduced UA level

Neuroligin 2 is exclusively localized to inhibitory synapses

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adavosertib) arrest tumour cells in an unscheduled S phase but appear less toxic to quiescent ovarian follicles, although formal reproductive-toxicology data are pending [140, 141]