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Derived from a compound found in the French lilac (goats rue), Metformin is now the most widely used oral medication for managing type 2 diabetes globally, often prescribed off-label for conditions like polycystic ovary syndrome (PCOS) and, in some cases, for weight loss

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The IRS treats prescribed compounded medicines as Section 213(d) qualified expenses when they are medical care, but some HRA plans now explicitly exclude compounded GLP-1s, and FSA and HSA administrators may require additional substantiation

It catalyzes the peroxidase cycle through a Cys mechanism in which GSH and protein disulfide isomerases,are alternative substrates, allowing rapid reactivity with thioredoxin (Trx) or proteins related to most other CysGPx