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250,251 At the same time, ethanol can directly affect the activities of MAT, BHMT, and other enzymes, interfere with Met metabolism, inhibit GSH formation, and weaken the antioxidant capacity of cells

It is a 53-amino-acid polypeptide weighing roughly 6,200 Daltons, which immediately makes it too large to cross intact stratum corneum at meaningful concentrations

Nonetheless, the inability of OPCs to differentiate into mature oligodendrocytes in the aged brain is not currently debated, and it likely contributes to the reduced capacity for remyelination and declining oligodendrocyte population (Sim et al., 2002

What is the follow up plan if there is a side effect