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Bariatric surgery, which includes procedures like sleeve gastrectomy and gastric bypass, has long been considered an effective solution for severe obesity

Patients should temporarily discontinue GLP-1 medications before gastric emptying studies according to facility-specific protocols, which typically consider the half-life of the specific agent

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Electrophysiological and c-Fos mapping studies in rodent models have demonstrated that amylin receptor activation in these regions inhibits gastric emptying, reduces meal size, and activates downstream satiety circuits projecting to the hypothalamic arcuate nucleus (Lutz et al., Physiology & Behavior, 2010)