arsenic glutathione Nrf2 activation ameliorates cytotoxic effects of trioxide in acute promyelocytic leukemia cells through increased levels and arsenic efflux from cells Arsenic toxicity and its mitigation

arsenic glutathione

arsenic glutathione Nrf2 activation ameliorates cytotoxic effects of trioxide in acute promyelocytic leukemia cells through increased levels and arsenic efflux from cells Arsenic toxicity and its mitigation

Name: arsenic glutathione Nrf2 activation ameliorates cytotoxic effects of trioxide in acute promyelocytic leukemia cells through increased levels and arsenic efflux from cells Arsenic toxicity and its mitigation
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Description

Zubiaga, L

The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)