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The streak of pigmentation is thin, uniform, and does not involve the nail folds

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End Stage Renal Disease (ESRD) patients on maintenance hemodialysis may have low plasma carnitine concentrations and an increased ratio of acylcarnitine/carnitine because of reduced intake of meat and dairy products, reduced renal synthesis and dialytic losses

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Effectiveness varies based on individual metabolism, lifestyle, sun exposure, and skincare routine

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