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Many studies have shown a link between the risk of cardiovascular diseases and the production of TMA by intestinal bacteria, which is further converted to trimethylamine N-oxide (TMAO) by hepatic enzymes (Tang et al

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1 hour later, mice were gavaged with water (20 L per gram body weight) and singly placed in dry, sterile, empty cages with a wire bottom without bedding

KPV also acts through a receptor-independent mechanism: direct suppression of NF-B nuclear translocation, the master transcription factor for inflammatory gene expression