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Glutathione plays a pivotal role in most key physiological functions including but not limited to maintenance of cellular redox, neutralising free radicals, cell cycle regulation, proliferation, apoptosis, xenobiotic metabolism, and the recycling of other cellular antioxidants such as Vitamins C and E

Notably, TrxR1 exhibits elevated levels of expression across a spectrum of malignancies, encompassing hematological neoplasms such as lymphoma and multiple myeloma, underscoring its potential as a therapeutic target in oncology (185)