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Summary: Vitamin B12 treatment typically begins producing early haematological responses within 34 days, with neurological symptoms starting to improve within 12 weeks, though complete symptom resolution may require several weeks to months depending on deficiency severity and treatment route

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For SH-SY5Y/MYCN, the culture media was supplemented with 7.5 g/mL Blasticidin (Bio-Sciences) and 200 g/mL Geneticin (G418) (Thermo Scientific) for selection of the plasmid

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