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Erk phosphorylation, reduced by 84% with DOX, was increased by 370% following GHRP-6 treatment, indicating restoration of survival signaling, and this effect was not significantly influenced by the additional antagonists [2]

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Anti-IGF-1 receptor (IGF-1R) monoclonal antibodies (mAbs) were developed for clinical use in treating advanced stage cancers 22,23,24 , including Ganitumab, which remains under investigation as a combination therapy in clinical trials targeting Rhabdomyosarcoma (NCT03041701) and Ewing Sarcoma (NCT02306161), for which it recently received orphan drug status