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Therefore, the evaluation of the efficacy of the delivery via transporter-mediated approach should be performed with the main focus on unbound concentration of the active (parent) drug at the specific site in the brain where the target is located

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doi: 10.1016/j.ccell.2018.07.014 96

He literally planted the seeds for the continuing evolution of broccoli, and specifically sulforaphane, as an effective agent for reducing the burdens of disease in humans as reviewed in his Reflections writing in the Journal of Biological Chemistry [146] and as reflected in a literature that now exceeds 3000 papers