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However, their long life-span, penetration through the bloodbrain barrier (BBB) 13 , and high therapeutic doses may allow them to directly act on central nervous system GLP-1Rs 12 , thereby causing CNS-dependent side effects

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Although our previous study of D2R-DAT interaction was conducted in mouse tissues, we have confirmed the existence of D2R-DAT interaction using rat striatal tissue and that TAT-DAT NT peptide was able to disrupt the D2R-DAT interaction in this study (Fig