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Additionally, GLP-1 receptor activation improves insulin secretion and decreases glucagon secretion in a glucose-dependent manner, helping to stabilize blood sugar levels

Acknowledgement The author wishes to thank Daniel Soares Freire, MD, PhD for providing medical writing and editorial assistance on behalf of Springer Healthcare

Among the possible recombinant GIP analogues, the analogues that simultaneously conserve Tyr 1 and Ile 7 show similar GLP-1R-activating activity to natural GIP, and Ile 7 is more important than Tyr 1 .23 Importing Ile 7 into MAR709 caused a sharp decline in GLP-1 activity