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Excretion Pathways Limited data on combined excretion indicates: Primarily renal elimination of peptide fragments Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways No evidence of accumulation in chronic dosing studies (animal models) The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all three components

Nonetheless, there are some commonalities with the other peptides in their pattern of interaction with the TMD

Disclaimer: This article is not intended to provide medical advice

Funding Authors declare no funding for this work