Patients with a history of medullary thyroid carcinoma, pancreatitis, or severe gastrointestinal disease should avoid these medications
Key nutrients include myo-inositol, CoQ10, active folate (5-MTHF / Quatrefolic), vitamin D, vitamin E, zinc, selenium and antioxidants
The rare but serious side effects identified in trials include pancreatitis (0.3%), gallbladder events (1.4%), and acute kidney injury (0.7%)
This momentum in drug development for MASH underscores a growing need for translatable preclinical models that accurately reflect human MASH pathology, support mechanistic insights, and predict treatment responses for streamlining the transition from preclinical to clinical development