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to reduce excess body weight and maintain weight reduction long term in adults and pediatric patients aged 12 and older with obesity, and in adults with overweight plus at least one weight-related comorbid condition

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The primary conflict in patients is typically not rooted in the metabolic foundation, and blind use may incur costs such as gastrointestinal adverse reactions and the loss of lean body mass (190, 191, 200)

The gut adaptation that made your maintenance dose comfortable fades during a break, so early-dose side effects such as nausea can briefly return as you re-titrate