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High-dose methylcobalamin (500-2500 mcg) is generally well-tolerated with few common side effects, as its a water-soluble vitamin excess of which is excreted in urine

49 Further evaluation on a double-blind, randomized phase 1 clinical trial in 98 patients with T2DM on current management with metformin revealed that Danuglipron was generally well tolerated and associated with minimal side effects such as nausea, dyspepsia, and vomiting comparable with the ones observed with the use of injectable GLP-1RA

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