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5.7 Metabolic Acidosis Hyperchloremic, non-anion gap, metabolic acidosis (decreased serum bicarbonate below the normal reference range in the absence of chronic respiratory alkalosis) has been reported in patients treated with phentermine and topiramate extended-release capsules [see Adverse Reactions (6.1)]

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Key Takeaways Semaglutide lowers appetite, but consistent eating at or above maintenance calories will still prevent weight loss