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Adding a second injection-only compound raises injection-site irritation risk and can compound fatigue during the early adaptation weeks

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2,14,15 It should be reserved for specific clinical circumstances in which a rectal examination is unreasonable (e.g., in a child with a history of trauma) or the diagnosis is uncertain

We learned from previous work conducted in our laboratory that the N-terminus of the molecule is critical for binding and activity [96-98]