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Water Retention: Minimal, with low likelihood of fluid retention

Option 3: Research peptides (gray area but low risk) Pathway: Find reputable research peptide supplier Order "for research purposes" Use at own risk Advantages: Much cheaper than prescription No doctor visit required Wide selection available Quick access Disadvantages: Gray legal area (not illegal but not approved) No medical oversight Quality varies by supplier No recourse if something goes wrong You assume all risk If going this route: Use reputable suppliers only (third-party testing) Start with conservative doses Understand you're in gray area legally (though low practical risk) See our best peptide vendors guide for quality sourcing

In addition, cotadutide was shown to be safe and, in common with the GLP-1 analogues, was associated with dose-dependent gastrointestinal adverse events, especially nausea and vomiting [82]