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UK guidance typically recommends: Loading doses of colecalciferol (e.g., total of approximately 300,000 IU over 6-10 weeks) for confirmed deficiency Maintenance therapy with 8002,000 IU daily thereafter Higher doses may be required for malabsorption conditions Before starting high-dose vitamin D, check corrected calcium and renal function

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The age-related decline in melatonin and dampening of circadian rhythms likely contributes to sleep problems, metabolic and cognitive decline, and increased vulnerability to age-related diseases