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Signs: When ALM appears on the palm or sole, it looks like a bruise or an elevated, thickened patchusually tan, brown, or black, with variations in color and irregular borders

avoiding misdiagnosis, this image as well as the video clip shows the mucosa with melanosis coli

4 Discussion Obesity is a highly prevalent, chronic, relapsing disease requiring long-term management ( via the incretin pathway, stimulating insulin and inhibiting glucagon secretion in a glucose-dependent manner, leading to lower blood glucose levels with low risk for hypoglycaemia ( To determine the role of semaglutide in obese mice, we performed intraperitoneally injections of semaglutide to HFD-induced obese mice, whereas the NCD and HFD groups were treated with saline for 12 weeks

Especially those reducing pathogenic responses have been tested for therapeutic purposes in clinical trials