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So the similarity in the constraints of 1-Cys and 2-Cys reduction facilitates this second Cys acquisition step, but an additional constraint is that the second Cys must be the resolving Cys and thus have a higher pKa than the existing Cys

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Because this is one of the most common musculoskeletal procedures, commercial payers, Medicare, and Medicaid all reimburse it routinely when documentation supports the diagnosis and necessity