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Effect of the dual glucosedependent insulinotropic peptide/gulcagonlike peptide 1 receptor agonist tirzepatide on lipid profile and waist circumference: a systematic review and metaanalysis

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However, independent lines of evidence continue to support involvement of FNDC5/irisin signaling in metabolic adaptation, bone remodeling, and neuroprotection, suggesting that early technical limitations may have obscured rather than invalidated its physiological relevance ( A key limitation for irisin translation remains the absence of a definitively identified receptor