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26 In addition, increased estrogen levels, as occurs during pregnancy or with exogenous estrogens, can further impair hepatic excretory function by downregulating NTCP and OATP1B1/1B3, which are responsible for the sinusoidal uptake of bile acids and organic anions into hepatocytes

Some of my published work hypothesized that it might actually be repressed by vitamin D because it has a sequence