While these medications arent approved for chronic inflammatory diseases such as rheumatoid arthritis (RA), many people with RA have been prescribed a GLP-1 to manage a coexisting condition
[10] [11] The risk with metformin alone is lower but still requires monitoring P-glycoprotein (P-gp) and CYP3A4 substrates : Berberine may inhibit these important drug transporters and enzymes, potentially affecting levels of medicines with a narrow therapeutic index, including: Immunosuppressants (ciclosporin, tacrolimus) Direct oral anticoagulants (DOACs) and warfarin Digoxin Some statins (particularly simvastatin, atorvastatin) Anticoagulants and antiplatelet drugs : Theoretical increased bleeding risk Antihypertensive medications : Possible additive blood pressure-lowering effects When to seek medical advice : Persistent or severe gastrointestinal symptoms Signs of hypoglycaemia (shakiness, sweating, confusion, rapid heartbeat) Unexplained fatigue or jaundice (yellowing of skin or eyes) Any unusual symptoms after starting berberine Seek urgent medical help for severe hypoglycaemia (confusion, seizures, loss of consciousness) or signs of severe allergic reaction (difficulty breathing, swelling of face/throat)
Cloning and functional expression of the human islet GLP-1 receptor: Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
Gentle eyelid hygiene with diluted baby shampoo prevents bacterial buildup that commonly triggers styes, especially in people who wear makeup or contact lenses regularly
