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400 HFD is the standard method to induce obesity in animal models and results from the overconsumption of fat, which directly increases caloric intake

Is part of the motivation coming from his own personal experience

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Normally, less than 1% of any given oral berberine supplement gets put to use in the body, but a 2017 animal study showed that liposomal berberine is stored, absorbed, and used 16 times more than berberine on its own.1 31 Though more (human) studies are needed to verify this bioenhancing potential, the theory holds that your body may get more impact from Renues LIPO Berberine than from alternatives