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Many dermatologists and aesthetic professionals recommend a combined approach using both together produces synergistic results that exceed either alone

However, these studies have been small, conducted by the same research group, and lack rigorous placebo-controlled statistical comparisons

Nevertheless, several investigators have studied BT by studying mesenteric lymph node tissue at the onset of laparotomy in patients without sepsis or trauma, which is cultured with viable bacteria categorized and compared to the existing intestinal luminal bacteria