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Stimulant laxatives, such as Dulcolax, senna/sennosides, and Senokot (Bisacodyl)

Circanas data indicates some reversed behaviors after people return to regular lifestyles, with consumers going back to categories such as beverages, refrigerated and frozen foods, disposable housewares and tobacco

QA accumulation is associated with brain inflammation and cell death, and patients with advanced CKD exhibit elevated plasma KYN metabolites and QA, which uniquely correlate with fatigue and reduced quality of life (Saliba et al., 2024), supporting the role of gut-derived KYN metabolites in linking CKD to neuroinflammation

L.ZhaoL.et al (2022)