glp-1 ra cardiovascular benefits of glucagon-like peptide-1 receptor agonists Reducing Risk of Major Adverse

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DTrp2 also had no opioid receptor activity and was specific in action in that it did not release thyrotropin-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), or adrenocorticotropic hormone (ACTH), all of which derive from the pituitary gland

The theoretical benefit compared to the peptides is reduced receptor desensitisation and a different tolerability profile, though whether that translates to clinically meaningful differences in nausea, vomiting and discontinuation rates is still under investigation