gas pain on semaglutide What Causes and How Can I Calm It Quickly? Top 5 Common Semaglutide Side

& Verjee, Z

The SURMOUNT-5 trial, published in the New England Journal of Medicine in 2025, randomly assigned 751 adults with obesity to either tirzepatide or semaglutide for 72 weeks.[1] The results were clear: Average weight loss with tirzepatide: 20.2% Average weight loss with semaglutide: 13.7% Tirzepatide patients were also more likely to hit major milestones 10%, 15%, 20%, and even 25% body weight loss

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This can be ascribed to its modulatory effects on the NO-system [96,97,98,99,100] and prostaglandins-system [106,107], as mentioned above