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and Cotsarelius, G

Beyond pigmentation, afamelanotides broader therapeutic profile includes anti-inflammatory and anti-fibrotic effects: in animal models, -MSH analogs have reversed liver and skin fibrosis by modulating matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), and suppressing fibrogenic signals like TGF-1 and collagen synthesis

Both Type I collagen (structural support) and Type III collagen (flexibility and early-stage repair) went up

Patients who required invasive management (surgery, radiologic or endoscopic intervention) or died from postoperative complication where issued as severe morbidity (grade IIIV) 45