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189 Subsequently, tirzepatide has been extensively investigated in the SURPASS program, a comprehensive development initiative targeting T2DM that is inadequately controlled by various glucose-lowering regimens, including lifestyle alone (SURPASS-1), 190 metformin monotherapy (SURPASS-2), 191 metformin with or without sodium-glucose co-transporter 2 inhibitors (SGLT2i) (SURPASS-3), 192 combination therapy including metformin, SGLT2i, and sulfonylureas (SURPASS-4), 193 insulin glargine with or without metformin (SURPASS-5), 88 and insulin lispro with basal insulin (SURPASS-6)

Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity

Environmental factors, including exposure to ultraviolet (UV) radiation, pollution, and harsh weather conditions, also affect skin beauty

The first essential step is confirming whether cortisol elevation is pathological and identifying its underlying cause