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Furthermore, Nakamura et al

They are awaiting grant of a patent by the US Food and Drug Administration to be used for the treatment of melasma, freckles, lentigines and postinflammatory hyperpigmentation

Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (170, 209, 258, 259, 272, 273)

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