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According to this concept, lipid metabolism can regulate tumor hypoxia environment by activating hypoxia inducible factor (HIF) (200)

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79,80,81,82 NF-B-iNOS-COX-2 signaling pathway NF-B is a ubiquitous transcription factor activated following the phosphorylation (catalyzed by IB kinase) and dissociation of its inhibitor kappa-B subunit alpha (IB)