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The mesolimbic reward system represents a third mechanism through which GLP-1 affects eating behavior

Finally, although most of the evidence of a potential benefit of GLP-1 RAs in HF originates from CVOTs in type 2 diabetes, it may likely be in the weight management setting that the drug class could be of the highest clinical value, particularly in people with HFpEF

Combining Contrave with tirzepatide means you are taking three pharmacologically active compounds, bupropion, naltrexone, and tirzepatide, which creates additional complexity

The goal should be realistic, sustainable weight management rather than expecting appetite and body weight to remain exactly as they were during treatment