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SMURF2 primarily promotes the degradation of GSTP1 protein by catalyzing the polyubiquitination of GSTP1 at K121/191/55 sites, thereby promoting ferroptosis[73]

The Long-Term Impact of Glutathione Depletion Since glutathione is essential for protecting cells from oxidative stress and supporting liver function, its depletion can have widespread effects on overall health

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