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10.3389/FNAGI.2022.998292/PDF [DOI] [PMC free article] [PubMed] [Google Scholar] Yin J, Jin X, Shan Z et al (2017) Relationship of sleep duration with all-cause mortality and cardiovascular events: a systematic review and dose-response meta-analysis of prospective cohort studies

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Upon activation, autoreactive T lymphocytes differentiate into helper T (Th) cells, which secrete a variety of pro-inflammatory cytokines and chemokines that induce immune activation and inflammation ( T-reg: Regulatory T cells (Tregs) play a crucial role in cancer, autoimmune diseases, chronic inflammation, and infectious diseases by regulating self-tolerance and suppressing immune responses

The methionine loading results in an abnormal increase in homocysteinemia, revealing a defect in the transsulfuration pathway, which is attenuated by folic acid and/or pyridoxine supplementation